Creutzfeldt-Jakob-Genetics

Familial Creutzfeldt-Jakob-Genetics By Savannah Jackson and Courtney Johnson To have a child with this disease the parent can have a normal genotype or one of the parents may carry the defective gene. "In fCJD, the mutations in this gene cause the cells to produce an abnormal form of the prion protein instead of the normal form. In most cases, the patient with fCJD inherits the altered gene from one affected parent. In some people, a new mutation in the gene causes fCJD. Although such people most likely do not have an affected parent, they can pass the genetic change to their children"(//UCSF Memory and Aging Center ,2011).// Creutzfeldt-Jakob is passed from parent to child from a genetic mutation of the //PRNP// gene. It's inherited from one of the individual's parents. The abnormal gene produces a different form of PrPC, which then becomes PrPSc and causes the disease. No other forms of CJD are inherited.  An Example //:// //Mom: doesnt have cjd so her Genotype is cc// //Dad: does have cjd so his genotype is Cc or CC// //If the dad's genotype was Cc then about 50% of his children would have cjd.// //If the dad's genotype was CC then about 100% of his children would have cjd.//  __Creutzfeldt-Jakob-Homepage__ __

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